Electrospun PVP/PVA Nanofiber Mat as a Novel Potential Transdermal Drug-Delivery System for Buprenorphine: A Solution Needed for Pain Management

Over the past several decades, formulation of novel nanofiber-based drug-delivery systems has been a frequent focus scientists around world. Aiming to introduce nanofibrous transdermal system treat pain, nanofiber mats buprenorphine-loaded poly (vinyl pyrrolidone) (Bup/PVP) and poly(vinyl alcohol)/poly(vinyl (Bup/PVP/PVA) were successfully fabricated by electrospinning process for drug delivery. Similarly, PVP PVP/PVA nanofibers in same conditions comparison. The viscosity electrical conductivity all solutions measured, characterized scanning electron microscopy (SEM), atomic force (AFM), Fourier transform infrared (FT-IR) spectroscopy contact angle analysis. showed considerable increase addition buprenorphine due polarity buprenorphine. SEM images smooth, fine porous structure without any adhesion or knot samples. analysis increased hydrophilicity wettability Bup/PVP/PVA compared Bup/PVP which can be attributed PVA. Attenuated total reflectance (ATR) FT-IR results confirmed that did not affect chemical integrity drug. For modification release rate, cross-linking was carried out using glutaraldehyde. Drug measurements high-performance liquid chromatography (HPLC) demonstrated exhibited better physical properties Bup/PVP. Furthermore, led an time. Thus, efficient biomaterial patches delivery against pain improving carrier retention providing controlled